Publications
Check out our recent work below!
Graphical Abstracts
Select Publications
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Pachytene piRNAs define a conserved program of meiotic gene regulation
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Protocol for assembling, prioritizing, and characterizing piRNA clusters using the piRNA Cluster Builder
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A comparative roadmap of PIWI-interacting RNAs across seven species reveals insights into de novo piRNA-precursor formation in mammals.
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Hierarchical length and sequence preferences establish a single major piRNA 3'-end.
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Functional editing of endogenous genes through rapid selection of cell pools (Rapid generation of endogenously tagged genes in Drosophila ovarian somatic sheath cells).
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Cellular abundance shapes function in piRNA-guided genome defense.
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Decoding the 5' nucleotide bias of PIWI-interacting RNAs.
Additional Publications
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A deficiency screen identifies genomic regions critical for sperm head-tail connection.
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Activity of the mammalian DNA transposon piggyBat from Myotis lucifugus is restricted by its own transposon ends.
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PIWI-interacting RNAs who, what, when, where, why, and how.
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A deficiency screen identifies genomic regions critical for sperm head-tail connection.
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Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes.
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Themes and variations on piRNA-guided transposon control.
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Transposase N-terminal phosphorylation and asymmetric transposon ends inhibit piggyBac transposition in mammalian cells.
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CRISPR-Cas9 Genome Editing and Rapid Selection of Cell Pools.
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An introduction to PIWI-interacting RNAs (piRNAs) in the context of metazoan small RNA silencing pathways.
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A non-radioactive, improved PAR-CLIP and small RNA cDNA library preparation protocol.
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Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas.
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PiRNAs Rise to Rescue Koalas.
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Aberrant expression of select piRNA-pathway genes does not reactivate piRNA silencing in cancer cells.
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Argonaute-miRNA Complexes Silence Target mRNAs in the Nucleus of Mammalian Stem Cells.
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A Small RNA-Based Immune System Defends Germ Cells against Mobile Genetic Elements.
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Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence.
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The making of a slicer: activation of human Argonaute-1.
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The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis.
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The structure of human argonaute-2 in complex with miR-20a.
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Probing the initiation and effector phases of the somatic piRNA pathway in Drosophila.
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The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs.
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TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing.
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TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells.