Research
Current Research
Small non-coding RNAs play vital roles in development and disease by regulating gene expression, defending against viruses, and silencing mobile genetic elements (transposons). Our research focuses on PIWI-interacting RNAs (piRNAs), which safeguard genome integrity and are essential for germ cell health and fertility. To unravel the molecular mechanisms of this RNA-based immune system, we integrate genetics, genomics, and biochemistry. These studies deepen our understanding of the fundamental processes protecting genome integrity in animals and humans and inform molecular strategies for technological and therapeutic advances.
Applying our Research
Maintaining genome stability is essential for cellular and organismal health, as its disruption is linked to diseases including infertility, inflammation, and cancer. Understanding RNA-guided genome protection opens paths for advancing fertility treatments and developing biomedical strategies to counteract genomic instability in disease.
Need for Further Study
Small RNA-guided molecular machines are found across all domains of life, yet we are only beginning to understand their diverse roles in gene regulation and genome surveillance. Unraveling these pathways is essential for elucidating their functions in health and disease and will continue to expand the molecular toolkit for research and therapeutic applications.
Genomes serve as life’s instruction manuals, guiding cell, tissue, and organ formation. Protecting their integrity is crucial for fertility and species survival. Our research focuses on specialized molecular guardians that safeguard germ cell genomes in animals and humans. By uncovering these protective mechanisms, we aim to strengthen our understanding of genome stability and develop new diagnostic and therapeutic strategies.